Mindful awareness is emerging in the fields of education, mental health, and medicine as an essential process that can promote effective learning, psychological well-being, empathy, and physiciological health.  This keynote address will examine recent scientific findings from the fields of neuroscience and from attachment research that implicate the central role of attunement in the promotion of well-being. There is an exciting overlap among secure infant-parent attachment, mindful awareness practices, and the integrative function of the prefrontal region of the human brain.  With this view we can propose that mindful awareness if a form of internal attunement that allows us to become our own best friend. The neural correlates of such an attuned self-relationship corrspond to those that promote flexible self-regulation and healthy interpersonal relationships.